Metronidazole has revealed evidence of mutagenic action in quite a few in vitro bacterial assay devices. Additionally, a dose-reaction boost in the frequency of micronuclei was noticed in mice following intraperitoneal injections and a rise in chromosome aberrations have been documented in sufferers with Crohn's ailment who were handled with 200-1200 mg/working day of metronidazole for 1 to 24 months.
There were no deaths or critical adverse functions related to drug therapy in clinical trials involving 800 non-pregnant Females who received METROGEL-VAGINAL.
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The following adverse reactions and altered laboratory tests are described With all the oral or parenteral use of metronidazole:
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Even though metronidazole has shown mutagenic activity in many in vitro assay units, reports in mammals (in vivo) have failed to demonstrate a potential for genetic destruction.
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